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Scientist I Scientist I
Ref No.: 18-14675
Location: Waltham, Massachusetts
Responsibility:
Perform in vitro and in vivo drug metabolism studies for discovery projects in various Sanofi R&D portfolios
Prepare routine in vitro samples for metabolism or MetID studies including but not limit to incubation with hepatocytes, liver microsomes or other biological matrices and processing of samples using protein precipitation, evaporating or concentrating samples.
Aid in performing routine tissue exposure, tissue binding and biomarker analysis in biological matrix including process the samples for LC-MS analysis
Assist the supervisor in maintaining documentation, safety inspection, and instrument log books.
Maintain general lab reagents and supplies inventory
Operate and maintain LC/MS systems

Basic Qualifications:
BS, MS, or Ph.D. degree in biology, chemistry, or pharmaceutical science discipline plus at least 10 years for BS, 5-7 years for MS or 2-4 years for Ph.D. of industrial experience in conducting drug metabolism studies using hepatocytes and liver microsomes is a must.
Strong technical skills in handling hepatocytes, cells, and other biological matrices is required
Experience in operating and maintaining LC and Thermo Scientific Orbitrap or AB Sciex triple-quadruple mass spectrometers is a plus.
Prior experience in Analyst® and Watson® software for quantitative analysis and automation using Tecan liquid handling system for drug metabolism assays is a plus.
Records in strong technical writing skill as evidenced by research paper, conference presentation, and patent publications, etc.
Skills and Experience
Required Skills: Drug metabolism, LC-MS, sample preparation, hepatocyte incubation, organization
Additional Skills: MS software, cell culture, problem solving, quantitative analysis
Preferred Qualifications:
Attention to details
Critical analytical and problem solving skills
Excellent communication and interpersonal skills
Strong commitment to the assigned tasks and striving for on-time delivery
Desire to work within a team in a highly dynamic environment