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Research Assistant
Ref No.: 18-06495
Location: Novato, California
The Research Assistant is involved with the design of protein purification processes suitable for manufacturing therapeutic proteins or gene therapy vectors, and with the transfer of those processes to manufacturing facilities. The Associate works primarily in the laboratory to design, carry out, and analyze experiments that lead to the design of effective processes.
The applicant must exercise technical discretion in the design and execution of varied experiments and projects. He or she provides quantitative analysis of data and interpretation of results, writes protocols, and contributes to technical reports. At times, he or she may evaluate complex methods, technologies, or laboratory equipment. He or she may adapt existing processes and develop new processes.
The applicant may provide assistance to manufacturing start-up, troubleshooting, and validation. Will be expected to contribute to scientific publications and regulatory submissions, attend external seminars.
More specifically, this position requires the following roles. The primary focus is laboratory experimental work:
Execute small-scale experiments to design, optimize, and characterize purification processes.
Perform experiments to determine operational ranges and robustness for various steps in purification processes.
Develop, perform and troubleshoot analytical assays required to support experiments (e.g., UV absorbance, SDS-PAGE, western blot, HPLC, enzyme activity, qPCR and ELISA).
Assist with process scale-up and transfer into the clinical manufacturing plant.
Order materials for the laboratory and maintain equipment and facility through targeted preventive maintenance.
Use pilot-scale equipment to process cell-culture harvests and to prepare purified proteins for animal studies or research.

Required Skills:
Broad technical proficiency in protein purification and analysis allowing effective execution of experiments
Able to use computers effectively for data analysis and presentation
Excellent communication skills, including scientific writing
Ability to mentor others and gain acceptance of ideas.
Desired Skills:
1+ years industry experience in purification process development
Expertise in protein chromatography, ultrafiltration, HPLC, and spectrophotometry
Expertise in viral vector purification