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Nektar is seeking a Sr. RA to provide hands-on in vivo research support for early and developing programs targeting immuno-oncology and inflammatory diseases. We are seeking someone who is highly proficient in in vivo drug administration by multiple routes and sample collection. Expertise in in vivo tumor models is required, and experience in auto-immune disease models is a plus. Basic skills in flow cytometry analysis of tissue samples is preferred.
Conducts pharmacological evaluation of test agents (small molecule and biologics) in subcutaneous and orthotopic in vivo models of oncology.
∙ Extensive experience in conducting in vivo tumor models, administering test articles (i.v., i.p., s.c. and p.o. required), and collecting samples. Will assist in or lead project teams in sample processing, homogenization, or generation of single-cell suspensions for ex vivo analysis.
∙ Collects and records clinical measurements and observations. Candidate will be responsible for entering data from multiple studies in a timely manner and must be able to communicate experimental results within the department effectively.
∙ Proficiency in in vitro cell culture, cell culture scale-up for implantation, cell banking and maintenance of frozen stocks utilizing aseptic technique is required.
∙ Maintains familiarity with current disease relevant in vivo models for testing efficacy of Client biologic and small molecules to support preclinical development and investigational new drug filings.
∙ Contributes to preclinical research through validation or development of new models.
∙ Experience in preparing basic formulations and dosing solutions is desired.
∙ Exercises technical discretion in the design, execution and interpretation of experiments that contribute to project strategies.
∙ Performs research and/or development independently or in collaboration with others.
∙ Maintains a high level of professional expertise through familiarity with scientific literature.
∙ Ensures compliance with good laboratory practices and other regulatory guidelines.
∙ Understands and implements study protocol according to AAALAC and other guidelines
Additional Requirements Include: Ability to work collaboratively within a team as well as independently, while displaying strong organizational and timely record-keeping skills. Ability to multi-task and perform work with a high degree of attention to detail while supporting programs in a fast-paced environment. Must have excellent analytical skills, strong organizational skills, and significant hands-on laboratory experience. The ideal candidate will provide and receive technical assistance to/from others in a wide range of laboratory-based activities/techniques in closely coordinated team setting. Must have a demonstrated working knowledge of scientific principles and problem solving abilities with good decision-making skills. Excellent oral and written communication skills, with the ability to independently write reports is essential. Must be able to demonstrate sound judgment within broadly defined practices and policies. Good computer skills are required, and a working knowledge of MS Word, Excel, PowerPoint, GraphPad Prism is a plus. Experience working in an FDA-regulated environment is highly desired.
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