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Scientist - Process Development - Viral Vector Upstream Process Development**
Ref No.: 20-04744
Location: Santa Monica, California

**Viral Vector Upstream Process Development**** Process Engineer 
Are you looking to be a member of the upstream development of the viral vector programs at a leading BioSciences Organziation? Are you looking to contribute to the development and scale up of the viral vector production with focus on viral vector cell line and cell culture development? . These activities can include lead clone selection, process optimization, scale-down model development and qualification, robustness studies, and process characterization.
If you are looking to work in these areas and support development of upstream technology platforms to integrate process, media and cell line development, consider applying to this position. 

In this role, you will:

• Execute laboratory studies in order to support process development or improvements
• Perform hands on work in a cell culture lab, specifically cell culture expansion, viral vector production as well as process scale up and implementation into GMP clinical production suites.
• Write and review technical documentation
• Perform process analysis and trend process performance
• Design and execute process development studies to develop a thorough understanding of operating and performance parameters

Required Skills:

• Knowledge of cell culture scale-up and engineering principles (e.g. growth rates, specific consumption/production rates, bioreactor aspect ratios, power calculations, gas transfer, shear stress)
• Knowledge of statistical DOE (design of experiments)
• Build, operate, and troubleshoot bench top and pilot scale bioreactors; compile and analyze results
• Excellent communication and presentation skills and aptitude for problem solving
• Candidate should be self-motivated, ambitious, organized, and collaborative

• BS/ MS degree in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline
• Previous experience with both adherent and suspension cell culture systems, transient transfection and/or stable cell lines is desired.
• A previous track record of culture process development experience such as cell passaging, formulation of media, aseptic technique processing, and managing reagents.
• Practical demonstration of hands on process development including use of statistical design of experiments is required. Experience with automation technologies is desired.
• Ability to think critically, and demonstrate troubleshooting and problem solving skills
• Excellent interpersonal, verbal and written communication skills are essential.
• Self-motivated with a strong sense of ownership in areas of responsibility and willingness to accept temporary responsibilities outside of initial job description
• Comfortable in a fast-paced environment and able to adjust workload based upon changing priorities.
• Ability to work and collaborate in cross functional teams, research, development, manufacturing in a fast pace and dynamic team setting.

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