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Research Associate II/III (DOE)
Ref No.: 24-94934
Location: South San Francisco, California
Start Date / End Date: 07/08/2024 to 01/10/2025
Job Title : Research Associate II/III (DOE)
Job Location : South San Francisco, CA 94080
Contract: 12 Months on W2

Job Description :
  • The Preclinical and Translational PKPD (PTPK) Department, is looking for an exceptional laboratory-based contract scientist to work in the investigative PK/ADME group in South San Francisco.
  • This position is to investigate the pharmacokinetics, biodistribution, metabolism, and the PKPD relationships of Client therapeutics in preclinical setting in support of early and late stage drug development.
  • The candidate will be responsible for designing and implementing in-vitro and in-vivo studies that includes cell based in-vitro assay, radiolabeled tissue distribution studies, ADME studies to understand the properties of protein and nucleotide therapeutics.
  • The candidate will interact and develop close partnerships across various functions including Research, Safety Assessment, PD Biomarker, Bioanalytical Assays, Clinical Sciences, Formulation and Regulatory. Additional component of the job will be sample/data analysis and presentation of results to cross-functional teams, department meetings, review committees, internal/external conferences, and regulatory agencies.
Job Responsibilities
  • Design and implement in-vitro and in-vivo studies to address ADME questions of protein and nucleotide therapeutic. Writing and submitting protocol to cross functional team for review.
  • Carry out sample analysis (including tissue processing) by using different analytical methods.
  • Characterize and identify possible biotransformation products from protein and nucleotide therapeutic in different biological matrices.
  • Interpret data and communicate results in department meeting and project team meeting.
  • Prepare presentation and report for conferences, manuscripts and regulatory documents.
Who you are
  • Candidate should be highly motivated individual with a passion for science, a curiosity of solving complex problem, attention to detail, as well as demonstrated effectiveness to work independently and in team settings.
  • The candidate should also be proficient in a broad variety of lab related technical skills (cell culturing, cell base assay, analytical chemistry, etc.).
  • You are expected to have some knowledge in basic pharmacology, drug metabolism (characterizing and identifying metabolite) and in PKPD relationship.
  • An individual with strong communication and collaboration skill, along with the ability to clearly articulate solution.
Education and experience
• A Bachelor's or Master's degree in Biology or Biochemistry with 0-3 years in the Research and Development experience.
• Must have demonstrated a general working knowledge of cell based assay, analytical techniques (HPLC, LSC, mass spectrometry and etc.), and laboratory skills. Understanding of PK concepts and the use of Client drug delivery system is preferred.
• Previous experience in chemistry, especially with working with radio-isotope, is a plus.
• Good oral and written communication skills are important as well as demonstrated effectiveness in working independently and in a team setting.