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Scientific - Research Associate-Scientific
Ref No.: 23-59506
Location: San Diego, California
Job Description: Job Title: Research Associate, Molecular Biology and Next Generation Sequencing (Sequencing Research & Genomics group)
Location: San Diego, CA (100% on-site)

The Sequencing Research & Genomics (SRG) group at *** (Client) is currently seeking a conscientious, talented, and motivated molecular biologist to join a highly innovative and collaborative NGS technology development team. The advertised position provides an exciting opportunity for the candidate to develop Client genomics assays and platforms, to understand our pre-clinical and clinical-stage assets. As part of the larger Informatics and Predictive Sciences organization at Client, the candidate will be in the unique position to engage with diverse scientific teams, utilizing enabling genomics tool to elucidate complex biological questions, with line of sight to benefit patient health. The position is for employment on a contract basis for 1 year, with potential to extend or convert.

• Lab operations include RNA/DNA extraction/purification, NGS library preparation & QC
• Development and benchmarking of high-throughput NGS technologies (e.g., DNA-Seq and RNA-Seq assays)
• Perform a wide variety of molecular biology techniques with minimal supervision and with an exceptional attention to details
• Perform occasionally cell culture and compound treatment of cells, along with functional assays related to drug response in cell lines
• Work independently and/or in collaboration with other team members on new assay and protocol development
• Develop and edit protocols and standard operating procedures
• Generate, organize, and maintain meticulous records on all conducted experiments

Skills/Knowledge preferred
• MS or Bachelor degree with 2-3+ years of professional experience in molecular biology (preferred), biology, biotechnology, or biochemistry
• Demonstrated expertise in molecular biology techniques, including DNA/RNA extraction & purification, NGS library preparation & QC, PCR, qPCR, cloning, etc.
• Extensive understanding of RNA-seq and DNA-seq NGS technologies, with a track record of utilizing such assays and an ability to troubleshoot the sequencing process end-to-end to improve NGS library quality
• Strong understanding of theory behind techniques, proficient reasoning skills in experimental design and optimizing wet lab techniques, coupled with an exceptional attention to details
• Excellent troubleshooting and problem-solving skills
• Experience with single-cell sequencing workflows, such as 10x Genomics is a plus
• Experience with assays such as targeted sequencing, multiplex PCR, ddPCR is a plus
• Competence with standard cell isolation, cell culture, compound treatment, FACS, FF and FFPE tissue handling is a plus
• Proficiency with MS Office suite, and ability to analyze and present genomic data
• Strong planning and organizational skills and comfort with systems e.g., Confluence, JIRA, SharePoint systems
• Commit to quality by rigorous and constant evaluation of own work

Additional Responsibilities:
• Drive the implementation and utilization of Client genomics assays across diverse research programs
• Foster impactful collaborative genomics initiatives within the organization
• Must be a strong team player with a proactive and positive attitude
• Ability to use technical skills and good time management to perform work efficiently and meet project timelines

Application Requirements:
• Cover Letter
• Curriculum Vitae