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Scientist I
Ref No.: 18-04590
Location: South San Francisco, California
Genentech
Scientist I
South San Francisco, CA

Duties:
  • The responsibilities of a DMPK-BA Associate Scientist/Scientist are to develop and/or oversee bioanalytical methods for the quantitative analysis of chemical entities (CEs) and their metabolites in plasma and other biological matrices, interpret and provide bioanalytical results to other scientists and project teams in support of drug development in a fast-paced environment.
  • Responsible for technical monitoring of Contract Research Organizations (CROs) involved in the bioanalysis supporting small molecule preclinical and clinical development.
  • Participating in CRO site selection and visits, technical support of method validation and bioanalysis, overseeing the transfer of bioanalytical methods to CROs, reviewing and reporting data in various formats and reviewing validation reports.
  • Specific training and refresher courses in the area of Good Laboratory Practice (GLP) compliance for preclinical study support will be required, as applicable.
Skills:
  • Understanding of various extraction techniques for biological samples, such as liquid-liquid, solid phase and protein precipitation and experience in using various LC-MS platforms (Sciex triple quadrupole or QTOF) and automation workstations.
  • Experience in the development, validation and implementation of bioanalytical methods in a GLP environment is a plus.
  • Experience with peptide or oligonucleotide bioanalysis is a plus.
  • Capable of introducing new technologies and new laboratory approaches and demonstrate the ability to interpret and communicate bioanalytical results in external meetings.
  • Experience with documentation of bioanalytical data, report writing, and laboratory data acquisition systems (Watson LIMS) are a plus.
  • Capable of managing projects with a high emphasis on quality and timelines while representing the bioanalytical function on project teams.
Education:
In most circumstances, the DMPK-BA Associate Scientist/Scientist will have a doctoral degree (Ph.D.) and 2 or more years relevant experience.