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Research Associate - Neuroscience
Ref No.: 19-07922
Location: South San Francisco, California
Research Associate
South San Francisco, CA

A position in the Translational Neuroscience group to support research and drug development for Client treatments of neurodegenerative disease. The candidate will be working as a part of a team that conducts in vivo characterization of animal models of neurodegeneration as well as pk/pd and efficacy studies with large and small molecules.

  • The successful candidate will be responsible for supporting in vivo dosing, mouse necropsy, tissue harvest and analysis of target engagement and efficacy of putative therapeutics in mouse models of disease.
  • Participate in managing flow of data from outsourced and internal studies to CALM for imaging and analysis.
  • Individuals will have the opportunity to be creative in their work, to develop or run existing biochemical assays, analyze and present data, and to publish original work.
  • The individual will interact with and communicate TN needs to other groups (BMI, DMPK) as part of a diverse and multidisciplinary team.
  • Experience handling rodents is essential; the ideal candidate should be familiar with multiple dosing methods, including p.o., i.p. and i.v.
  • Experience with standard necropsy procedures.
  • Adherence to animal protocols and compliance with basic ethical and regulatory requirements for animal handling are critically important.
  • Experience performing IHC/IF, confocal imaging, Western blots, and ELISAs is essential.
  • Additional experience using FACS/single cell technology + RNAseq is a plus.
  • Detail-oriented researcher with attention to good experimental design and comfort using graphing and statistical analysis software.
  • Strong organizational, communication, and interpersonal skills.
  • Team Oriented, dependable, self starter.
  • Ability to follow detailed verbal and written instruction.
  • BS in Neuroscience or related field plus 1-3 years research experience in pharmaceutical industry.