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Research Associate - Protein Sciences
Ref No.: 18-00555
Location: San Francisco, California
Position Type:Contract
Start Date: 04/25/2018
RESEARCH ASSOCIATE – PROTEIN SCIENCES
SAN CARLOS, CA

Project Description:
A growing San Francisco Bay area based immuno-oncology company focused on novel approaches to generate anti-tumor immunity, is seeking a qualified Research Associate/Sr. Research Associate who will play an integral role in moving our discovery research efforts into the clinic. We are seeking a talented and motivated team member to support our research efforts in developing our antibody-based immuno-oncology therapeutics. The candidate should have experience in the characterization of recombinant proteins and monoclonal antibodies, including protein over-expression, purification, and biophysical characterization for the development of biosensor (SPR or BLI) based assay platforms for screening/characterization of antibody binding and specificity.
  • Development of biosensor (SPR or BLI) based assay platforms for screening/characterization of antibody binding and specificity
  • Biophysical characterization of antibody stability and developability assessment using calorimetry (ITC, DSC), light scattering, and differential scanning fluorimetry (DSF) to support lead candidate selection
  • Organization and analysis of results, communicating and presenting findings in team meetings, and contributing to scientific publications
  • Troubleshooting and optimizing assays through data interpretation, identification of novel or alternate procedures and techniques, and timely execution
  • Ability to work in a team environment and adapt to changing company priorities

Required Skills:
  • Bachelor's or Master's degree in a life sciences discipline with at least five plus years of industry experience in developing assays.
  • Good understanding of biophysical characterization of antibodies is must.
  • SPR, BLI, DSC, DSF, FTIR, AUC, and DLS are highly desired
  • Experience in standard protein analytical techniques including electrophoresis, Western Blot, ELISAs, HPLC, UV-Vis spectrophotometry.
  • Proficiency in protein production and purification techniques (e.g., using peristaltic pumps, HPLC systems), ultrafiltration/diafiltration is a significant plus.
  • Motivation to learn and use new and emerging techniques for mammalian cell culture, protein production, flow cytometry, and gene manipulation in cells.
  • Excellent communication skills with the ability to work effectively in a dynamic and flexible team environment.
  • Ability to maintain detailed records of experimental methods and results.
  • Ability to critically interpret and effectively present data.
  • Adaptability to shifting priorities and changing work assignments.

This 3-6 month position starts ASAP.

Please E-MAIL your resume (attachment to email) with rate and availability to Karen: karen@alphaconsulting.com

ALPHA'S REQUIREMENT #18-00555
W2 ONLY MUST BE ELIGIBLE TO WORK IN THE U.S. AS AN HOURLY W2 EMPLOYEE